1,2,3,5-Tetrahydroimidazothienopyrimidin-2-ones
AssigneeDaiichi Seiyaku Co., Ltd.
InventorsFumiyoshi Ishikawa, Shinichiro Ashida
Life of this patent
Estimating the term…
Abstract
A 1,2,3,5-tetrahydroimidazothienopyrimidin-2-one represented by the formula: ##STR1## wherein one of Z.sub.1, Z.sub.2 and Z.sub.3 is a sulfur atom and the remaining two of Z.sub.1, Z.sub.2 and Z.sub.3 represent CH, R.sub.1 and R.sub.2 each represents a hydrogen atom, an alkyl group having 1 to 5 carbon atoms, a phenyl group, a chlorine atom or, when taken together R.sub.1 and R.sub.2 represent an alkylene chain of 3 to 5 carbon atoms, and R.sub.3 represents a hydrogen atom or an alkyl group having 1 to 5 carbon atoms, and a pharmaceutically acceptable acid addition salt thereof, which exhibit an excellent blood platelet anti-aggregatory activity and are useful as anti-thrombotic agents.
Claims6
A compound represented by the formula:
- ##STR13## wherein one of Z.sub.1,Z.sub.2 and Z.sub.3 is a sulfur atom and the remaining two of Z.sub.1, Z.sub.2 and Z.sub.3 represent CH, R.sub.1 and R.sub.2 each represents a hydrogen atom, an alkyl group having 1 to 5 carbon atoms, a phenyl group, or a chlorine atom or, when Z.sub.1 or Z.sub.3 is a sulfur atom, R.sub.1 and R.sub.2 taken together can represent an alkylene chain of 3 to 5 carbon atoms, and R.sub.3 represents a hydrogen atom or an alkyl group having 1 to 5 carbon atoms, and a pharmaceutically acceptable acid addition salt thereof.
A compound represented by the formula:
- ##STR14## wherein R.sub.1 and R.sub.2 each represents a hydrogen atom, an alkyl group having 1 to 5 carbon atoms, a phenyl group, a chlorine atom or, when taken together, R.sub.1 and R.sub.2 represent an alkylene chain of 3 to 5 carbon atoms, and R.sub.3 represents a hydrogen atom or an alkyl group having 1 to 5 carbon atoms, and a pharmaceutically acceptable acid addition salt thereof.
A compound represented by the formula:
- ##STR15## wherein R.sub.1 and R.sub.2 each represents a hydrogen atom, an alkyl group or, when taken together, R.sub.1 and R.sub.2 represent an alkylene chain of 3 to 5 carbon atoms, and R.sub.3 represents a hydrogen atom or an alkyl group having 1 to 5 carbon atoms, and a pharmaceutically acceptable acid addition salt thereof.
A compound represented by the formula:
- ##STR16## wherein R.sub.1 and R.sub.2 each represents a hydrogen atom or an alkyl group, and R.sub.3 represents a hydrogen atom or an alkyl group having 1 to 5 carbon atoms, and a pharmaceutically acceptable acid addition salt thereof.
Dependencies are inferred from the claim text.