Sugar acetals, their preparation and use
AssigneeTalres Development (N.A.) N.V.
InventorsLeslie A. W. Thelwall, Leslie Hough, Anthony C. Richardson
Life of this patent
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Abstract
Novel sugar acetals such as those of formula ##STR1## where R.sup.a is hydrocarbyl; R.sup.b and R.sup.c are hydrogen or hydrocarbyl; R.sup.3' R.sup.4' and R.sup.6' are hydrogen or R.sup.4' with R.sup.3' or R.sup.6' is ##STR2## are made from 1,4-linked reducing disaccharides by a new exchange acetalation process in which the solvent is omitted. The sugar acetals have free hydroxy groups on the ring which groups can be converted to other substituents, e.g. chlorodeoxy or fatty acid acyl. After deprotection, the corresponding derivative of the initial disaccharide is obtained.
Claims10
A sugar acetal of the general formula ##STR13## wherein:
- R.sup.a is C.sub.1-3 alkyl, phenyl or benzyl;
- R.sup.b is hydrogen, C.sub.1-3 alkyl, phenyl or benzyl;
- R.sup.c is hydrogen, C.sub.1-3 alkyl, phenyl or benzyl;
- R.sup.3', R.sup.4' and R.sup.6' are hydrogen atoms or one of R.sup.3' and R.sup.6' is a hydrogen atom and the other or R.sup.3' and R.sup.6' forms with R.sup.4' a group of formula ##STR14## in which R.sup.b and R.sup.c are as defined.
A sugar acetal of the formula ##STR15## wherein R.sup.1 is a C.sub.1 to C.sub.3 alkyl group, and R.sup.d is a C.sub.1 to C.sub.3 alkyl group.
4-O-(3,4,-O-isopropylidene-.b eta.-D-galactopyranosyl)-2,3:5,6-di-O-isopropylidene-1,1-di-O-methyl D-glucose.
4-O-(4,6 -O-isopropylidene-.alpha.-D-glucopyranosyl)-2,3:5,6-di-O-isopropylidene-1,1 -di-O-methyl D-glucose.
4-O-(.alpha.-D-gluco pyranosyl)-2,3:5,6-di-O-isopropylidene-1,1-di-O-isopropylidene-1,1-di-O-met hyl D-glucose.
Dependencies are inferred from the claim text.