Method for manufacturing dipeptides
AssigneesSagami Chemical Research Center, Ajinomoto Co., Inc., Toyo Soda Mfg. Co.
InventorsKiyotaka Oyama, Shigeaki Nishimura, Yuji Nonaka, Tsutomu Hashimoto, Keiichi Kihara
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Abstract
An improvement in a method for manufacturing dipeptides from an N-substituted aspartic acid and a phenylalanine lower alkyl ester. The two starting materials are allowed to react with each other in the presence of an immobilized metallo-proteinase in an organic solvent immiscible with water. The enzyme can be recovered for reuse thereof. The loss of materials due to the hydrolysis of the phenylalanine lower alkyl ester is reduced, so that use of the phenylalanine lower alkyl ester in a nearly stoichiometric quantity suffices for the reaction to ensure an improved yield and reduction in cost of industrial production.
Claims10
A method for manufacturing a dipeptide from an N-substituted aspartic acid and a phenylalanine lower alkyl ester, said method comprising subjecting said N-substituted aspartic acid and said phenylalanine lower alkyl ester to a reaction in an organic solvent immiscible with water in the presence of a water-containing immobilized metallo-proteinase.
Dependencies are inferred from the claim text.