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US 4,284,720 AGranted
Process for the preparation of 19-hydroxy steroids of the androstane and pregnane series
AssigneeSchering Corporation
InventorKarl Petzoldt
Life of this patent
Estimating the term…
Abstract
10-Methyl steroids of the androstane or pregnane series are converted to the corresponding 19-hydroxy steroid by fermentation with a fungal culture of the genus Nigrospora.
Claims3
A process for preparing a 19-hydroxy steroid of the formula ##STR3## wherein X and Y each is hydrogen or together represent a carbon-carbon bond or a methylene group,
- Z is hydrogen, fluorine, chlorine or methyl, and
- R is hydrogen or an acyloxy group of 1-8 carbon atoms,
- comprising fermenting at 10-methyl steroid of the formula ##STR4## wherein X, Y, Z and R are as defined above, with a fungal culture of the genus Nigrospora and isolating said 19-hydroxy steroid.
Dependencies are inferred from the claim text.