Pharmaceutically active imidazole derivatives

A method for the treatment or prophylaxis of a thrombo-embolic disorder of a mammal including man comprising the administration to the mammal of a non-toxic, anti-thrombo-embolic amount of 1-cyclooctylmethylimidazole or a pharmaceutically acceptable acid addition salt thereof.

A pharmaceutical formulation, for the treatment or prophylaxis of a thrombo-embolic disorder in a mammal comprising a non-toxic, anti-thrombo-embolic amount of an imidazole of the formula ##STR9## in which A is a straight or branched, saturated or unsaturated acyclic hydrocarbon radical of from 1 to 3 carbon atoms, n is 0 or 1, and R is a cycloalkyl or cycloalkenyl radical of from 4 to 9 carbon atoms and optionally substituted by one, two, three or more alkyl radicals and containing from 1 to 4 carbon atoms, or, when n is 1, A and R together form n alkyl radical of from 4 to 7 carbon atoms or an alkenyl or alkynyl radical from 4 to 9 carbon atoms, the imidazole being the free base or a pharmaceutically acceptable salt thereof, together with a pharmaceutically acceptable carrier therefor.

A pharmaceutical formulation for the treatment or prophylaxis of a thrombo-embolic disorder in a mammal comprising a non-toxic, anti-thrombo-embolic amount of 1-cyclooctylmethylimidazole or a pharmaceutically acceptable acid addition salt thereof, in association with a pharmaceutically acceptable carrier therefor.

A tablet for the treatment or prophylaxis of a thrombo-embolic disorder in a mammal having a non-toxic, anti-thrombo-embolic amount of 1-cyclooctylmethylimidazole or a pharmaceutically acceptable salt thereof.

A pharmaceutical formulation for the treatment or prophylaxis of a thromo-embolic disorder in a mammal comprising a non-toxic, anti-thrombo-embolic amount 1-Cyclooctylvinylimidazole or a pharmaceutically acceptable salt thereof in association with a pharmaceutically acceptable carrier therefor.

A pharmaceutical formulation for the treatment or prophylaxis of a thromo-embolic disorder in a mammal comprising a non-toxic, anti-thromo-embolic amount 1-Cyclooctylethyl) or a pharmaceutically acceptable salt thereof in association with a pharmaceutically acceptable carrier therefor.

A pharmaceutical formulation for the treatment or prophylaxis of a thromo-embolic disorder in a mammal comprising a non-toxic, anti-thromo-embolic amount 1-(2-Cycoolctylethyl) imidazole or a pharmaceutically acceptable salt thereof in association with a pharmaceutically acceptable carrier therefor.

A pharmaceutical formulation for the treatment or prophylaxis of a thromo-embolic disorder in a mammal comprising a non-toxic, anti-thromo-embolic amount 1-(3-Cyclooctylpropyl) imidazole or a pharmaceutically acceptable salt thereof in association with a pharmaceutically acceptable carrier therefor.

A pharmaceutical formulation for the treatment or prophylaxis of a thromo-embolic disorder in a mammal comprising a non-toxic, anti-thromo-embolic amount 1-Cyclononylmethylimidazole or a pharmaceutically acceptable salt thereof in association with a pharmaceutically acceptable carrier therefor.

A pharmaceutical formulation for the treatment or prophylaxis of a thromo-embolic disorder in a mammal comprising a non-toxic, anti-thromo-embolic amount 1-(Cyclobutylmethyl) imidazole or a pharmaceutically acceptable salt thereof in association with a pharmaceutically acceptable carrier therefor.

A pharmaceutical preparation in dosage unit form adapted for administration to obtain an anti-thrombo-embolic effec, comprising, per dosage unit, an anti-thrombo-embolic-effective non-toxic amount of an compound selected from the group consisting of an imidazole of the formula ##STR10## in which A is a straight or branched, saturated or unsaturated acyclic hydrocarbon radical of form 1 to 3 carbon atoms, n is 0 or 1, and R is a cycloalkyl or cycloalkenyl radical of from 4 to 9 carbon atoms and optionally substituted by one, two, three or more alkyl radicals each containing from 1 to 4 carbon atoms, or, when n is 1, A and R together form an alkyl radical of from 4 to 7 carbon atoms or an alkenyl or alkynyl radical of from 4 to 9 carbon atoms, the imidazole being the free base and pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier.

A pharmaceutical formulation for the treatment or prophylaxis of a thromo-embolic disorder in a mammal comprising a non-toxic, anti thromo embolic amount 1-Cyclohex-e-enylmethylimidazole or a pharmaceutically acceptable salt thereof in association with a pharmaceutically acceptable carrier therefor.

A pharmaceutical formulation for the treatment or prophylaxis of a thromo-embolic disorder in a mammal comprising a non-toxic, anti-thromo-embolic amount 1-(Cyclohept-2-enylmethyl) imidazole or a pharmaceutically acceptable salt thereof in association with a pharmaceutically acceptable carrier therefor.

A pharmaceutical formulation for the treatment or prophylaxis of a thromo-embolic disorder in a mammal comprising a non-toxic, anti-thromo-embolic amount 1-cyclopentylimidazole or a pharmaceutically acceptable salt thereof in association with a pharmaceutically acceptable carrier therefor.

A pharmaceutical formulation for the treatment or prophylaxis of a thromo-embolic disorder in a mammal comprising a non-toxic, anti-thromo-embolic amount 1-cycloheptylimidazole or a pharmaceutically acceptable salt thereof in association with a pharmaceutically acceptable carrier therefor.