Back to results
US 4,284,640 AGranted
Ethylene derivatives
AssigneeSmith Kline & French Laboratories Limited
InventorsGraham J. Durant, John C. Emmett, Charon R. Ganellin, Hunter D. Prain
Life of this patent
Estimating the term…
Abstract
The compounds are ethylene derivatives which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A compound of this invention is 1-nitro-2-methylamino-2-[2-((4-methyl-5-imidazolyl)methylthio)ethylamino]e thylene.
Claims6
A compound of the formula:
- ##STR8## wherein X and Y, which may be the same or different, are hydrogen, nitro, cyano or SO.sub.2 Ar but are not both hydrogen;
- Het' is thiadiazolyl unsubstituted or substituted by amino;
- R is hydrogen, lower alkyl or Het-(CH.sub.2).sub.m Z(CH.sub.2).sub.n ;
- Z is sulphur or methylene;
- m is 0, 1 or 2 and n is 2 or 3 provided that the sum of m and n is 3 or 4;
- Het is an oxazolyl, isoxazolyl or triazolyl ring unsubstituted or substituted by lower alkyl, hydroxyl, halogen or amino or a thiadiazolyl ring unsubstituted or substituted by amino, said Het' and Het being attached at a ring carbon;
- and Ar is phenyl unsubstituted or substituted by halogen or methyl or a pharmaceutically acceptable acid addition salt thereof.
4 more elements
Dependencies are inferred from the claim text.