Pharmaceutical compositions with central depressant and antipsychotic activity having a butyrophenone derivative which is substituted in the 4-position and a C-(2-benzofuranyl)-piperidine or C-(2-benzofuranyl)-tetrahydro-pyridine

A pharmaceutical composition with central depressant and antipsychotic activity which contains, as first active ingredient, a butyrophenone derivative of the formula I ##STR4## in which Pip is a piperidino radical which is substituted in the 4-position by hydroxyl and a radical selected from halophenyl, trifluoromethylphenyl and lower alkylphenyl, or a pharmaceutically acceptable acid addition salt thereof, and as second active ingredient, an unsubstituted or substituted C-(2-benzofuranyl)-piperidine or C-(2-benzofuranyl)-tetrahydropyridine of the formula II ##STR5## wherein R.sub.1 is hydrogen, an alkyl group containing at most 4 carbon atoms, the allyl, 3-oxobutyl, 3-hydroxybutyl, 2-propynyl or cyclopropylmethyl group, R.sub.2 is hydrogen or a methyl group, R.sub.3 is hydrogen, halogen having an atomic number up to 35, a lower alkyl or alkoxy group, the trifluoromethyl group or a cycloalkyl group containing 5 to 8 carbon atoms, R.sub.4 is hydrogen, a lower alkyl group or halogen having an atomic number up to 35, or R.sub.3 and R.sub.4 together are a 1,3-butadienylene radical in the 4,5-position, corresponding to a fused benzene ring, or a trimethylene radical in the 5,6-position, A is the ethylene group and B is the methylene group, or A is the methylene group and B is the ethylene group, and each of X and Y is hydrogen or together are an additional bond, or a pharmaceutically acceptable acid addition salt thereof, the ratio of the first and second active ingredient being from 1:2 to 1:100, together with at least one conventional carrier or adjunct.