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US 4,284,634 AGranted
1,4-Dihydropyridine derivatives, and pharmaceutical method of the same
AssigneeFujisawa Pharmaceutical Co., Ltd.
InventorYoshinari Satu
Life of this patent
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Abstract
1,4-dihydropyridine derivatives of the general formula ##STR1## having vasodilating and anti-hypertensive activity, processes for preparing same, and pharmaceutical compositions thereof for treating cardiovascular diseases.
Claims50
A compound of the formula:
- ##STR35## wherein R.sub.1 is unsubstituted phenyl, phenyl monosubstituted with halogen, nitro, hydroxy, halo(lower)alkyl, lower alkyl, lower alkoxy, lower alkenyloxy, cyano, lower alkoxycarbonyl or lower alkylsulfamoyl, and disubstituted phenyls selected from 2-chloro-5-nitro, 2-3 and 3-4 dichloros and 3-4 dimethoxy,
- R.sub.2 and R.sub.3 are lower alkoxycarbonyl, halo(lower)alkoxycarbonyl, hydroxy(lower)alkoxycarbonyl, lower alkoxy(lower)alkoxycarbonyl, phenyl(lower)alkoxycarbonyl, phenyl(lower)alkoxy(lower)alkoxycarbonyl, phenoxy(lower)alkoxycarbonyl, N,N-(di)-(lower)alkylamino(lower)alkoxycarbonyl and N-lower alkyl-N-phenyl(lower)alkylamino(lower)alkoxycarbonyl,
- R.sub.4 is hydroxy(lower)alkyl or gem-di(lower)alkoxy(lower)alkyl, and
- R.sub.5 is hydrogen, lower alkyl, or the same as R.sub.4.
1 more element
Dependencies are inferred from the claim text.