Stabilized water-in-oil emulsions
OwnerRuey J. Yu, Eugene J. Van Scottinventors
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Abstract
Stable water-in-oil emulsions useful as vehicles for cosmetics or for therapeutic compositions to be topically applied are disclosed. The emulsions utilize a concentration of from 0.2 to 2% by weight of magnesium oxide or magnesium hydroxide as a stabilizing agent. The stabilizing agent may be admixed with either the oil or the aqueous phase, and use thereof will permit incorporating up to 70% water in the total composition without loss of stability during either prolonged storage, or exposure to freezing and thawing.
Claims34
A method for stabilizing a water-in-oil emulsion for topical application to the human body, so that said emulsion will be stable when stored for two months and stable when subjected to freezing with subsequent thawing to room temperature comprising:
- admixing an oil base dispersion medium, an emulsifying agent, and a water based, aqueous dispersed phase, and
- a stabilizing effective amount of up to about 2%, by weight, of a member selected from the group consisting of magnesium hydroxide and magnesium oxide.
A method for producing a stable water-in-oil emulsion comprising:
- providing a dispersion medium consisting of a plurality of members selected from the group consisting of petrolatum, mineral oil, beeswax, isopropyl myristate, isopropyl palmitate, squalene, squalane, tocopheryl acetate, lanolin, wax, spermaceti, hydrogenated vegetable oil, chicken oil, and suet fat;
- admixing an emulsifier therewith selected from the group consisting of sorbitan monooleate, sorbitan sesquioleate, and sorbitan trioleate;
- providing an aqueous phase consisting of a plurality of members selected from the group consisting of water, sorbitol, propylene glycol, 1,3-butanediol, and glycerin;
- admixing from 0.2 to 2% of a stabilizing agent selected from the group consisting of magnesium hydroxide and magnesium oxide with said aqueous phase;
- separately heating said phases to 75.degree.-80.degree. C.;
- pouring the aqueous phase into the dispersion phase with agitation until the mixture congeals.
A method for producing a stable water-in-oil emulsion comprising:
- providing a dispersion medium consisting of a plurality of members selected from the group consisting of petrolatum, mineral oil, beeswax, isopropyl myristate, isopropyl palmitate, squalene, squalane, tocopheryl acetate, lanolin, wax spermaceti, hydrogenated vegetable oil, chicken oil, and suet fat;
- admixing an emulsifier therewith selected from the group consisting of sorbitan monooleate, sorbitan sesquioleate, and sorbitan trioleate;
- providing an aqueous phase consisting of a plurality of members selected from the group consisting of water, sorbitol, propylene glycol, 1,3-butanediol, and glycerin;
- admixing from 0.2 to 2% of a stabilizing agent selected from the group consisting of magnesium hydroxide and magnesium oxide with said dispersion medium;
- separately heating said aqueous phase and said dispersion medium to 75.degree.-80.degree. C.;
- pouring said aqueous phase into said dispersion medium with agitation until the mixture congeals.
A method for producing a stable water-in-oil emulsion comprising:
- providing a dispersion medium consisting of a plurality of members selected from the group consisting of petrolatum, mineral oil, beeswax, isopropyl myristate, isopropyl palmitate, squalene, squalane, tocopheryl acetate, lanolin, wax, spermaceti, hydrogenated vegetable oil, chicken oil, and suet fat;
- admixing an emulsifier with said dispersion medium selected from the group consisting of sorbitan monooleate, sorbitan sesquioleate, and sorbitan trioleate;
- providing an aqueous phase consisting of a plurality of members selected from the group consisting of water, sorbitol, propylene glycol, 1,3-butanediol, and glycerin;
- separately heating said phases to 75.degree.-80.degree. C.;
- pouring the aqueous phase into the dispersion medium with agitation until the mixture congeals;
- admixing from 0.2 to 2% of a stabilizing agent selected from the group consisting of magnesium hydroxide and magnesium oxide with said mixture.
A stable water-in-oil emulsion for use as a vehicle for topical application to the human body with cosmetic or medicinal compositions comprising:
- an oil phase dispersion medium containing a plurality of members selected from the group consisting of petrolatum, mineral oil, beeswax, isopropyl myristate, isopropyl palmitate, squalene, squalane, tocopheryl acetate, lanolin, wax, spermaceti, hydrogenated vegetable oil, chicken oil, and suet fat;
- an emulsifier admixed therein selected from the group consisting of sorbitan monooleate, sorbitan sesquioleate, and sorbitan trioleate, and sorbitan monostearate;
- an aqueous phase dispersed therein consisting of from 30 to 70% by weight of the total composition, of a plurality of members selected from the group consisting of water, sorbitol, propylene glycol, 1,3-butanediol, dextrose, and glycerin;
- and
- a stabilizing agent dispersed throughout said emulsion selected from the group consisting of magnesium oxide and magnesium hydroxide present in a concentration of from 0.02 to 2% by weight of the total composition.
A method for improving the efficacy of a medicinal compound selected from the group consisting of hydrocortisone, triamcinolone acetonide, and 6-aminonicotinamide which is effective to alleviate the symptoms of inflammatory skin diseases psoriasis and exzema by topical application to involved areas of the human body comprising:
- providing a stabilized water-in-oil emulsion vehicle for said compound which is stable when stored for two months and stable when subjected to freezing with subsequent thawing to room temperature by admixing an oil based dispersion medium, an emulsifying agent, and a water based dispersion phase with a stabilizing agent present in a stabilizing effective amount of up to about 2%, by weight selected from the group consisting of magnesium hydroxide and magnesium oxide;
- whereby when an anti-inflammatory effective amount of said compound in said vehicle is topically applied to inflamed areas of the human body to alleviate the symptoms of said inflammation , said vehicle will provide a moist and occlusive covering thereof.
Dependencies are inferred from the claim text.