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US 4,284,556 AGranted
7,8-Amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
AssigneeSmithKline Corporation
InventorsKenneth G. Holden, Carl Kaiser, Joseph Weinstock
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Abstract
A group of 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines whose structures have amino, hydroxy substituents at the 7,8-positions of the benzazepine nucleus is disclosed. Novel intermediates and routes of synthesis used for preparing them are also described. The end products have pharmacodynamic activity.
Claims9
A compound of the formula:
- ##STR7## in which:
- R is hydrogen, halo or lower alkyl of 1-3 carbons;
- R.sub.1 and R.sub.2 are hydroxy, amino, acetamido or methylsulfonamido with the proviso that one of R.sub.1 and R.sub.2 is always hydroxy and R.sub.1 and R.sub.2 are not both hydroxy;
- R.sub.3 is hydrogen, halo, methyl, methoxy, methylthio or hydroxy;
- and
- R.sub.4 is hydrogen, allyl or methyl;
- together with pharmaceutically acceptable, acid addition salts thereof.
4 more elements
Dependencies are inferred from the claim text.