US 4,284,506 A · Biomedical devices

Abstract

The present invention is directed to improved separatory devices employing polyurethane forming compositions, such as hollow fiber separatory devices intended to be used in biomedical applications. The separatory device employs at least one separatory membrane, suitable for the intended end use application, which is secured, potted or sealed in a housing using a cured polyurethane composition. The improvement comprises utilizing as the potting agent a polyurethane composition comprising the reaction product of an NCO-terminated prepolymer and a hydroxy terminated lactone derived polyester. The lactone polyester comprises the reaction product of a lactone such as caprolactone, and a polyol such as 1,6-hexane diol. The lactone derived polyester imparts to the polyurethane-forming composition a desirable balance of properties, including low mix viscosity, high reactivity, i.e., low gel and demold times, and acceptable hardness values, when used as a potting agent in biomedical separatory devices.

Claims10

Dependent claims

In a separatory device capable of use in biomedical applications wherein at least one separatory membrane is secured in a housing, in a manner sufficient to perform the selected biomedical function, by means of a flexible cured polyurethane composition provided by reacting a first component comprising an NCO-terminated prepolymer with a second component comprising at least one polyol, the improvement comprising using as said polyurethane composition the reaction product of:

A. at least one of said NCO-terminated prepolymers, and
B. at least one hydroxyl-terminated lactone polyester having an average molecular weight of between about 200 and about 1000 comprising the reaction product of:
1. at least one lactone represented by the structural formula:
##STR6## wherein n is an integer which can vary from 1 to about 10, and R is selected from the group consisting of hydrogen, alkyl, cycloalkyl, and alkoxy groups, having from about 1 to about 6 carbon atoms;
and
2.

3 more elements

In a process for preparing a separatory device capable of use in a biomedical application by securing a portion of at least one separatory membrane in a housing using a cured polyurethane composition provided by reacting a first component comprising at least one NCO-terminated prepolymer with a second component comprising at least one polyol, the improvement comprising mixing and reacting said NCO-terminated prepolymer of the first component with at least one hydroxyl-terminated lactone polyester having an average molecular weight of between about 200 and about 1000 comprising the reaction product of:

1. at least one lactone represented by the structural formula:
##STR8## wherein n is an integer which can vary from 1 to about 10, and R is selected from the group consisting of hydrogen, alkyl, cycloalkyl, and alkoxy groups, having from about 1 to about 6 carbon atoms;
and
2. at least one saturated difunctional polyol selected from the group consisting of
(a) glycols represented by the structural formula:
HO--CH.sub.2 --(CR'.sub.2).sub.n --CH.sub.2 --OH
wherein n is an integer which can vary from about 0 to 12, and R' is selected from the group consisting of hydrogen and an alkyl group having from about 1 to about 6 carbon atoms;
and
(b) cycloaliphatic polyols represented by the structural formula:
##STR9## wherein R is an alkyl group having from about 1 to about 6 carbon atoms and Y is a primary hydroxyl group.

7 more elements

Dependencies are inferred from the claim text.

Biomedical devices

Life of this patent

Biomedical devices

Life of this patent

Abstract

Claims10