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US 4,283,575 AGranted
2-Decarboxy-2-hydroxymethyl-19-hydroxy-6a-carba-PGI.sub.2 compounds
AssigneeThe Upjohn Company
InventorJohn C. Sih
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Abstract
The present invention provides novel 2-decarboxy-2-hydroxymethyl-19-hydroxy-6a-carba-PGI.sub.1 compounds which are useful for pharmacological purposes, e.g., anti-asthmatic indications.
Claims4
A prostacycline-type compound of the formula ##STR3## wherein L.sub.3 is (1) --(CH.sub.2).sub.n --, wherein n is one to 5, inclusive,
- (2) --(CH.sub.2).sub.p --CF.sub.2 --, wherein p is 2, 3, or 4, or
- (3) --CH.sub.2 CH.dbd.CH--;
- wherein M.sub.2 is ##STR4## wherein Q is oxo, .alpha.-H:.beta.-H, .alpha.-OH:.beta.-R.sub.4, or .alpha.-R.sub.4 :.beta.-OH,
- wherein R.sub.4 is hydrogen or alkyl of one to 4 carbon atoms, inclusive,
- wherein R.sub.5 and R.sub.6 are hydrogen, alkyl of one to 4 carbon atoms, inclusive, or fluoro, being the same or different, with the proviso that one of R.sub.5 and R.sub.6 is fluoro only when the other is hydrogen or fluro;
- wherein R.sub.9 is hydrogen or hydroxyl;
- and
- wherein X is
- (1) trans--CH.dbd.CH--,
- (2) cis--CH.dbd.CH--,
- (3) --C.tbd.C--, or
- (4) --CH.sub.2 CH.sub.2 --.
9 more elements
Dependencies are inferred from the claim text.