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US 4,283,550 AGranted
1-Descarboxy-1-ketoester(ketoacid)-prostaglandins
AssigneeAmerican Cyanamid Company
InventorMiddleton B. Floyd, Jr.
Life of this patent
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Abstract
This disclosure describes certain 11-hydroxy and 11-deoxy-1-ketocarboxylic acid prostanoic acids and derivatives useful as bronchodilators, hypotensive agents, anti-ulcer agents or intermediates.
Claims32
Compounds of the formula ##STR38## wherein R.sub.2 is selected from the group hydroxy and C.sub.1 to C.sub.7 alkoxy;
- X is selected from the group cis or trans --CH.dbd.CH-- and --CH.sub.2 --CH.sub.2
- C.sub.13 C.sub.14 is selected from the group trans --CH.dbd.CH-- and --CH.sub.2 --CH.sub.2 --;
- n is the integer 2, 3 or 4;
- and
- R.sub.3 is selected from the group consisting of:
- ##STR39## Wherein R.sub.4 is hydrogen or methyl;
- R.sub.5 is selected from the group consisting of C.sub.4 -C.sub.7 alkyl;
- R.sub.6 is selected from the group consisting of C.sub.3 -C.sub.6 alkyl;
- R.sub.7 is selected from the group consisting of C.sub.2 -C.sub.4 alkyl;
- R.sub.8 is selected from the group consisting of C.sub.1 -C.sub.2 alkyl;
- R.sub.11 is selected from the group consisting of C.sub.3 -C.sub.7 alkyl;
- p is an integer from 0 to 3;
- q is 1 or 2;
- Z is a divalent radical selected from the group consisting of --O-- and --CH.sub.2 --;
- and t is selected from the group consisting of hydrogen, chloro, fluoro, dichloro, trifluromethyl, methoxy;
- the racemic mixtures thereof;
- the mirror images thereof and where R.sub.2 is hydroxy the pharmaceutically acceptable salts thereof.
14 more elements
Dependencies are inferred from the claim text.