Reductive alkylation of nitrogen heterocycles
AssigneeBASF SE
InventorsNorbert Goetz, Leopold Hupfer
Life of this patent
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Abstract
A process for the preparation of aralkylamines of the formula ##STR1## where R.sup.1 is hydrogen, an aliphatic hydrocarbon radical, a cycloaliphatic radical or alkoxy, R.sup.2, R.sup.3 and R.sup.4 are hydrogen or alkyl, X.sup.1, X.sup.2, X.sup.3 and X.sup.4 are hydrogen or alkyl, A is ##STR2## X.sup.5, X.sup.6, X.sup.7, X.sup.8, X.sup.9 and X.sup.10 are hydrogen or alkyl and n is 2, 3 or 4, by reacting a secondary amine with a carbonyl compound in the presence of hydrogen and of a hydrogenation catalyst which comprises palladium, mixed with zinc, cadmium, manganese and/or a rare earth metal oxide, on an inert carrier.
Claims1
A process for the preparation of an aralkylamine of the formula I ##STR9## where R.sup.1 is hydrogen, an aliphatic hydrocarbon radical of 1 to 10 carbon atoms, a cycloaliphatic radical of 5 to 7 carbon atoms or alkoxy of 1 to 6 carbon atoms,
- R.sup.2, R.sup.3 and R.sup.4 are hydrogen or alkyl of 1 to 4 carbon atoms,
- X.sup.1, X.sup.2, X.sup.3 and X.sup.4 are hydrogen or alkyl of 1 to 4 carbon atoms,
- A is ##STR10## X.sup.5, X.sup.6, X.sup.7, X.sup.8, X.sup.9 and X.sup.10 are hydrogen or alkyl of 1 to 4 carbon atoms and
- n is 2, 3 or 4,
- by reacting a secondary amine of the formula II ##STR11## where X.sup.1, X.sup.2, X.sup.3, X.sup.4 and A have the above meanings with a carbonyl compound of the formula III ##STR12## where R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the above meanings and the bond shown in broken lines is a double bond or a single bond,
- wherein the reaction is carried out in the presence of hydrogen and of a hydrogenation catalyst which consists essentially of palladium, mixed with zinc, cadmium, manganese and/or a rare earth metal oxide, on an inert carrier.
Dependencies are inferred from the claim text.