3-O-Demethyl derivatives of Sannamycin C and antibiotic AX-127B-1
AssigneeAbbott Laboratories
InventorWilliam Rosenbrook, Jr.
Life of this patent
Estimating the term…
Abstract
3-O-demethylsannamycin C, 3-O-demethyl-antibiotic AX-127B-1 and their 4-N- and 2'-N-acyl and alkyl derivatives are provided. The compounds are broad spectrum antibiotics and anti-bacterial agents.
Claims25
A 3-O-demethylsannamycin C or antibiotic AX-127B-1 derivative represented by the formula ##STR4## wherein:
- R is hydrogen or methyl, R.sub.2 and R.sub.3 are the same or different members of the group consisting of hydrogen, acyl of the formula ##STR5## wherein R.sub.10 is loweralkyl, aminoacyl, diaminoacyl, N-loweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, loweralkyl, aminoloweralkyl, diaminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, N-loweralkylaminohydroxyloweralkyl and N,N-diloweralkylaminohydroxyloweralkyl;
- R.sub.4 and R.sub.5 are hydrogen or amino with the limitation that one of either R.sub.4 or R.sub.5 must be hydrogen;
- R.sub.6 and R.sub.7 are selected from the group consisting of hydrogen, hydroxy, amino and chloro with the limitation that one of either R.sub.6 or R.sub.7 must be hydrogen;
- R.sub.8 and R.sub.9 are hydrogen or hydroxy with the limitation that one of either R.sub.8 or R.sub.9 must be hydrogen;
- and the pharmaceutically acceptable salts thereof.
3-O-Demethylsannamycin C or a pharmaceutically acceptable salt thereof.
3-O-Demethyl-antibiotic AX-127B-1 or a pharmaceutically acceptable salt thereof.
3-O-Demethyl-2'-N-deslysyl-antibiotic AX-127B-1 or a pharmaceutically acceptable salt thereof.
3-O-Demethyl-2'-N-des-lysyl-4-N-beta-lysyl-antibiotic-AX-127B-1 or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.