Production of antibiotics WS-3442 A, B, C, D and E, and their acyl derivatives
AssigneeFujisawa Pharmaceutical Co., Ltd.
InventorsHiroshi Imanaka, Junzi Hosoda, Kazuyoshi Jomon, Heiichi Sakai, Ikuo Ueda, Daizou Morino
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Abstract
Production of antibiotic WS-3442 A, B, C, D and E, and their acyl derivatives thereof, the production of antibiotic WS-3442 A, B, C, D and E being a new method by culturing a new species of Streptomyces and their acyl derivatives of said antibiotics being prepared by acylating said antibiotics with an acylating agent. The acyl derivative of antibiotic WS-3442 A, B, C, D and E has antimicrobiological activity and is also useful for intermediate for preparing Cephalosporin derivatives having antimicrobiological activity.
Claims9
A process for the production of antibiotic WS-3442 selected from the group of WS-3442 A, B, C, D and E in which
- WS-3442 A has following chemical structure:
- ##STR9## WS-3442 B has following chemical structure:
- ##STR10## WS-3442 C has following chemical structure:
- ##STR11## WS-3442 D has following chemical structure:
- ##STR12## WS-3442 E has following chemical structure:
- ##STR13## which comprises cultivating a WS-3442-producing strain of Streptomyces wadayamensis in an aqueous nutrient medium under submerged aerobic conditions until a substantial antibiotic activity is imparted to said medium by the production of the WS-3442 and recovering the WS-3442.
Dependencies are inferred from the claim text.