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US 4,283,417 AGranted
Bronchodialation with 13,14-dihydro-15-alkenyl prostaglandins
AssigneePfizer Inc.
InventorsJames F. Eggler, Hans-Jurgen E. Hess
Life of this patent
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Abstract
The invention discloses certain novel 13,14-dihydro-15-alkenyl prostaglandins and 13,14-dihydro-15-alkynyl prostaglandins and analogs of each as well as the novel intermediates employed in their preparation. The 9-oxo compounds of this novel series demonstrate selective bronchodilator activity, certain of these are also useful as antisecretory agents.
Claims5
A method of selectively inducing bronchodilation in a mammal in need of such therapy which comprises administering to said mammal a brochodilating amount of a compound of the formula ##STR76## wherein R is hydrogen or biphenylyl;
- R.sup.1 is a member selected from the group consisting of hydrogen and alkyl having from one to eleven carbon atoms;
- Q is a member selected from the group consisting of oxygen, ##STR77## and mixtures of ##STR78## and Z is a member selected from the group consisting of ##STR79##
Dependencies are inferred from the claim text.