3-Amino or amido-2-(1H-indol-3-yl) propanoic acid derivatives
AssigneeMiles Laboratories, Inc.
InventorsRobert N. Schut, Max E. Safdy, Enrique Hong
Life of this patent
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Abstract
Disclosed are compounds characterized by the structural formula: ##STR1## Various compounds circumscribed by the foregoing formula in which: R is H, CH.sub.3 or CH.sub.2 CH.sub.3, R' is H, or ##STR2## X is H, F or OCH.sub.3, Y is H or Cl, and Z is H or ##STR3## are therapeutically useful as anti-hypertensive agents.
Claims23
3-Amino or amido-2-(1H-indol-3-yl)propanoic acid compounds characterized by the formula:
- ##STR21## wherein:
- R is H, CH.sub.3 or CH.sub.2 CH.sub.3,
- R' is H or ##STR22## X is H, F or OCH.sub.3, Y is H or Cl, and
- Z is H or ##STR23## provided that:
- (i) when X is F;
- Y, Z and R' are H and R is H or CH.sub.3 ;
- (ii) when X is H, Y is Cl, Z is H, R is CH.sub.3 and R' is H;
- and
- (iii) when X is OCH.sub.3 ;
- Y is H provided further that when Z and R' are H, R is CH.sub.3 ;
- when Z is H and R' is ##STR24## R is H and when Z is ##STR25## R' is ##STR26## and R is CH.sub.2 CH.sub.3.
Methyl 3-amino-2-(5-methoxy-1H-indol-3-yl) propanoate hydrochloride.
A method of treating hypertension in an individual requiring such treatment which method comprises administering to such individual an anti-hypertensive amount of a compound of the formula:
- ##STR30## wherein:
- R is H, CH.sub.3 or CH.sub.2 CH.sub.3,
- R' is H or ##STR31## X is H, F or OCH.sub.3, Y is H or Cl, and
- Z is H or ##STR32## provided that:
- (i) when X is F;
- Y, Z and R' are H and R is H or CH.sub.3 ;
- (ii) when X is H, Y is Cl, Z is H, R is CH.sub.3 and R' is H;
- and
- (iii) when X is OCH.sub.3 ;
- Y is H provided further that when Z and R' are H, R is CH.sub.3, when Z is H and R' is ##STR33## R is H and when Z is ##STR34## R' is ##STR35## and R is CH.sub.2 CH.sub.3.
Dependencies are inferred from the claim text.