Thiopropionamides, and the pharmaceutical compositions
AssigneeScience Union et Cie
InventorsCharles Malen, Pierre Roger, Michel Laubie
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Abstract
This invention relates to omega-mercaptopropionylamides, the nitrogen atom of which is included as a ring atom of a cyclic amino acid. The application also discloses a process for producing said compounds which comprises reacting an omega-mercaptopropionic acid, or a functional derivative thereof, with a cyclic amino acid. This invention further relates to pharmaceutical compositions incorporating such an omega-mercaptopropionylamide as active ingredient together with a pharmaceutically-acceptable carrier or vehicle, and a method of employing said compounds. They find a use in human therapy, namely, as antihypertensive agents.
Claims8
A compound of the formula ##STR19## where R is hydrogen, loweralkyl, loweralkanoyl, phenylloweralkyl or phenyl, where each of such phenyl rings may be substituted with one to three substituents selected from the group consisting of halogen, trifluoromethyl, lower alkyloxy, vinyl, lower alkylenedioxy, hydroxy and lower alkyl;
- R.sub.2 is hydrogen, loweralkyl or lower cycloalkyl;
- Z is sulfur, sulfoxide or sulfonyl;
- R.sub.3 is hydrogen or loweralkyl;
- m is 1;
- n is 1;
- p is 0, 1, or 2;
- and
- X is an amino group.
Dependencies are inferred from the claim text.