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AssigneeDegussa AG
InventorsJurgen Engel, Axel Kleemann, Fritz Stroman, Klaus Thiemer
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There are prepared compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen or together represent a second bond between the carbon atom carrying R.sub.1 and R.sub.2, R.sub.1 also can be a hydroxy group, R.sub.3 is hydrogen, a C.sub.3 -C.sub.8 cycloalkyl group or a C.sub.1 -C.sub.20 alkyl group, which optionally can also contain one or two hydroxy groups and the groups R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are the same or different and are hydrogen, C.sub.1 -C.sub.6 -alkyl groups or halogen atoms, their N-oxide, their quaternary salts and their acid addition salts. There are also described processes for their production. The compounds possess especially an antischemic and blood pressure increasing activity.
A compound having the formula ##STR31## where R.sub.1 is hydrogen or hydroxy, R.sub.2 is hydrogen or R.sub.1 and R.sub.2 together represent a second bond between the carbon atoms carrying R.sub.1 and R.sub.2, R.sub.3 is a C.sub.3 -C.sub.8 cycloalkyl group or a C.sub.1 -C.sub.20 alkyl group containing one or two hydroxy groups and the groups R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are hydrogen, C.sub.1 -C.sub.6 -alkyl groups or halogen atoms, an N-oxide thereof, a quaternary salt thereof with a compound of the formula R.sub.8 Y where R.sub.8 is alkyl of 1 to 20 carbon atoms and Y is chlorine, bromine or iodine or an acid addition salt thereof with a therapeutically acceptable acid.
Dependencies are inferred from the claim text.