Aroylethenylpiperidinobutyrophenone antipsychotic agents
AssigneeRichardson-Merrell Inc.
InventorsAlbert A. Carr, Robert A. Farr
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Abstract
4-Aroylethnyl-1-piperidinobutyrophenone derivatives and pharmaceutically acceptable salts thereof of the following general structure: ##STR1## wherein R is hydrogen, alkyl, alkoxy, halogen or trifluoromethyl; and R' is hydrogen or halogen, are useful as antipsychotic agents. The novel compounds are produced by aldol condensation of an acetophenone with a protected 4-(4-formyl-1-piperidino)-butyrophenone.
Claims12
A compound of the formula ##STR6## wherein R is hydrogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, fluorine, chlorine, bromine, or trifluoromethyl;
- and R' is hydrogen, fluorine, chlorine or bromine;
- and pharmaceutically acceptable acid addition salts thereof.
A pharmaceutical composition comprising in unit dosage form from about 1 mg to 50 mg of a compound of the formula ##STR8## wherein R is hydrogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, fluorine, chlorine, bromine or trifluoromethyl;
- and R' is hydrogen, fluorine, chlorine or bromine;
- and a significant amount of a pharmaceutically acceptable carrier.
A compound of the formula ##STR9## wherein R' is hydrogen, fluorine, chlorine or bromine;
- and Z is selected from dialkoxy of 1-8 carbon atoms in each alkoxy group and alkylenedioxy of 2-8 carbon atoms and 2-3 carbon atoms in the chain.
A compound of the formula ##STR10## wherein R' is hydrogen, fluorine, chlorine or bromine;
- and Z is selected from dialkoxy of 1-8 carbon atoms in each alkoxy group and alkylenedioxy of 2-8 carbon atoms and 2-3 carbon atoms in the chain.
Dependencies are inferred from the claim text.