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US 4,283,402 AGranted
6-N-Heterocyclyl-3-tetrazolyl-penicillins
AssigneeMerck & Co., Inc.
InventorJohn Hannah
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Abstract
This invention relates to a new class of penicillins (I) and their pharmaceutically acceptable salts which are useful as antibiotics: ##STR1## wherein the stylized radical (hereafter referred to as R'): ##STR2## attached to the 6-amino nitrogen moiety of the penicillin nucleus represents a mono- or polycyclic N-containing heterocyclic group; and R is, inter alia, hydrogen, substituted and unsubstituted: alkyl, aryl, alkenyl, heterocyclylalkyl, heterocyclylalkenyl, aralkenyl, aralkyl, --NR.sub.2, COOR, CONR.sub.2,--OR, or CN.
Claims4
A compound having the structural formula:
- ##STR212## and the pharmaceutically acceptable salts and esters thereof wherein:
- R' is selected from the group consisting of:
- ##STR213## wherein the dotted line indicates both saturated and unsaturated rings;
- and
- wherein:
- R is hydrogen, alkyl having from 1-6 carbon atoms, substituted alkyl having from 1-6 carbon atoms wherein the substituent is chloro, fluoro, hydroxyl, alkoxyl (C.sub.1-6), carboxyl, amino, sulfo and mono- and dialkylamino wherein each alkyl has 1-6 carbon atoms substituted and unsubstituted phenylaklkyl and phenylalkenyl having 7-12 carbon atoms wherein the substituent is selected from chloro, fluoro, carboxyl, amino, cyano, hydroxyl and sulfo;
- R.sup.3 is chloro, fluoro, hydroxyl, carboxyl, sulfo, cyano, amino, mono- and dialkylamino, alkoxyl alkyl having from 1-6 carbon atoms, substituted alkyl having 1-6 carbon atoms wherein the substituent is carboxyl, cyano, alkoxyl having 1-6 carbon atoms, phenyl and phenyloxy;
- n is an integer selected from 0 to 3.
5 more elements
Dependencies are inferred from the claim text.