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US 4,283,391 AGranted
Pamamycin
AssigneeSt. Louis University
InventorsBurton M. Pogell, Pamela A. McCann
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AssigneeSt. Louis University
InventorsBurton M. Pogell, Pamela A. McCann
Estimating the term…
A new antibiotic named pamamycin is derived from S. alboniger. The antibiotic compound is neutral and terpene-like as derived from S. alboniger. The antibiotic is produced in conjunction with substances which either stimulate or inhibit the transition of substrate to aerial mycelia. Pamamycin may be separated by thin layer chromatography. The antibiotic displays particular R.sub.f values in thin layer chromatography as well as a particular antimicrobial spectrum for its use. The molecular formula is 621 and the elemental formula thereof is C.sub.36 H.sub.63 NO.sub.7 as determined by mass spectroscopy. The structure is believed to be a saturated alkane and terpene-like. In vivo tests with Staphylococcus aureus indicate that pamamycin is a potent inhibitor of both DNA and RNA synthesis and this antibiotic has present utility in a 1% solution to degerminate hospital walls.
Pamamycin which has an elemental composition of C.sub.36 H.sub.63 NO.sub.7 and is defined by an NMR spectrum containing no exchangeable hydrogens, a multiplet centered at approximately 0.9 ppm indicating methyl groups, and multiplets in the range between 1.25-2.0 ppm and 2.0-2.75 ppm showing that the bulk of the hydrogen is methine and methylene groups and finally a triplet at 1.1 ppm indicating loss of a propyl group and being characterized by an IR spectrum which is highly aliphatic and showing an absence of aromatic, --OH, and --NH groups, further characterized by a peak at 1725 cm.sup.-1 indicating a carbonyl group and further characterized by no amide 1 and amide 2 stretch bands (1600-1700 cm.sup.-1) indicating the nitrogen present is as a tertiary linkage.
Dependencies are inferred from the claim text.