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US 4,283,350 AGranted
19,20-Didehydro-PG.sub.2 amides
AssigneeThe Upjohn Company
InventorJohn C. Sih
Life of this patent
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Abstract
The present invention provides novel 19,20-didehydro-PG.sub.2 amides methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.
Claims1
A compound of the formula ##STR4## wherein D is (1) cis--CH.dbd.CH--CH.sub.2 --(CH.sub.2).sub.g --CH.sub.2 --,
- (2) cis--CH.dbd.CH--CH.sub.2 --(CH.sub.2).sub.g --CF.sub.2 --,
- (3) cis--CH.sub.2 --CH.dbd.CH--CH.sub.2 --CH.sub.2 --,
- (4) trans-(CH.sub.2).sub.3 --CH.dbd.CH--,
- wherein Q is ##STR5## wherein R.sub.5 is hydrogen or methyl, wherein R.sub.7 and R.sub.8 are hydrogen, alkyl of one to 12 carbon atoms, inclusive,
- benzyl, or phenyl, being the same or different. wherein R.sub.2 is hydrogen, hydroxyl, or hydroxymethyl;
- wherein R.sub.3 and R.sub.4 are hydrogen, methyl, or fluoro, being the same or different, with the proviso that one of R.sub.3 and R.sub.4 is fluoro only when the other is hydrogen or fluoro;
- wherein W is ##STR6## and wherein X is cis--or trans--CH.dbd.CH-- or --C.tbd.C--.
4 more elements
Dependencies are inferred from the claim text.