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US 4,283,342 AGranted
Anticancer agents and methods of manufacture
AssigneeUniversity of Delaware
InventorSeymour Yolles
Life of this patent
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Abstract
A therapeutic metal coordination compound, particularly useful as an anticancer agent, which is the reaction product of a hydroxy quinone and a cisplatinum (II) compound substituted with chloro ligands and ammonia or derivatized ammonia ligands and the process for its manufacture.
Claims9
A metal coordination compound comprising, as a therapeutic portion,
- (a) A multi-ring quinone having at least one hydroxy group in a ring fused to the quinone ring as ligand,
- (b) chelated at keto and hydroxy groups with the platinum metal
- (c) in a cis-dichloro platinum (II) compound having two platinum metal coordinate bonds each joined to a member of the group consisting of ammonia, mono-substituted ammonia and ammonia radicals connected one to the other by single valence bonds through adjacent carbons of a carbon ring compound, and
- (d) additional cis-dichloro platinum (II) compound not bonded to the hydroxy quinone but coordinated to said platinum which is bonded to said hydroxy quinone, and, as a non-therapeutic portion,
- (e) excess platinum in the form of tetrachloro-platinate anion.
2 more elements
The method of manufacturing a metal coordination compound according to claim 8 wherein said solvent is a member of the group dimethyl formamide, dimethyl acetamide, methylene chloride, methyl pyrolidone, hexamethyl phosphoramide.
Dependencies are inferred from the claim text.