Process for the purification of tryptophane and derivatives of tryptophane
AssigneeDeutsche Gold- und Silber-Scheideanstalt vormals Roessler
InventorsTheodor Lussling, Alfred Maierhofer, Paul Scherberich
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Abstract
Tryptophane and tryptophane derivatives are purified by treating them in an inert solvent at a temperature between about 20.degree. C. and the boiling point of the mixture with a salt of dithionous acid. Preferably there is used as solvent a mixture of water and a lower aliphatic carboxylic acid. Normally a single treatment results in a pure, colorless, satisfactory product.
Claims14
In a process for purifying a substance which is (1) tryptophane or (2) tryptophane substituted in the 2 or 5 position of the ring by chlorine, bromine, fluorine, alkyl of 1-4 carbon atoms, hydroxy or benzyloxy or (3) tryptophane substituted on the NH.sub.2 group by formyl, acetyl, chloroacetyl, fluoroacetyl, benzoyl, phthaloyl toluenesulfomyl or carbobenzoxy, the improvement consisting essentially of treating the substance to be purified in a solvent inert under the conditions of purification at a temperature between about 20.degree. C. and the boiling point of the mixture with an alkali metal dithionite.
Dependencies are inferred from the claim text.