Pharmacologically active peptides
AssigneeEli Lilly and Company
InventorRobert T. Shuman
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Abstract
Compounds of the formula ##STR1## and pharmaceutically acceptable non-toxic acid addition salts thereof, in which L and D define the chirality; R.sub.1 is hydrogen or C.sub.1 -C.sub.3 primary alkyl; R.sub.2 is C.sub.1 -C.sub.4 primary or secondary alkyl, allyl, cyclopropylmethyl, C.sub.1 -C.sub.2 hydroxyalkyl, or --(CH.sub.2).sub.m --U--CH.sub.3 in which U is --S-- or >S--O and m is 1 or 2; R.sub.3 is cyclopropylmethyl or allyl; and Z is --CH.sub.2 OR.sub.4, ##STR2## in which R.sub.4 is hydrogen, acetyl, or acetoxymethyl and R.sub.5 is C.sub.1 -C.sub.3 alkyl; are useful analgesic agents.
Claims13
A compound of the formula ##STR10## and pharmaceutically acceptable non-toxic acid addition salts thereof, in which L and D define the chirality;
- R.sub.1 is hydrogen or C.sub.1 -C.sub.3 primary alkyl;
- R.sub.2 is C.sub.1 -C.sub.4 primary or secondary alkyl, allyl, cyclopropylmethyl, C.sub.1 -C.sub.2 hydroxyalkyl, or --(CH.sub.2).sub.m --U--CH.sub.3 in which U is --S-- or >S--O and m is 1 or 2;
- R.sub.3 is cyclopropylmethyl;
- and
- Z is --CH.sub.2 OR.sub.4, ##STR11## in which R.sub.4 is hydrogen, acetyl, or acetoxymethyl and R.sub.5 is C.sub.1 -C.sub.3 alkyl.
Dependencies are inferred from the claim text.