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US 4,282,365 AGranted
Dibenz[b,e]oxepin compounds
AssigneeMerck & Co., Inc.
InventorsJoshua Rokach, Edward J. Cragoe, Jr., Clarence S. Rooney
Life of this patent
Estimating the term…
Abstract
Novel dibenz[b,e]oxepin derivatives are employed in the treatment and control of allergic conditions such as allergic asthma.
Claims17
A compound selected from the group consisting of 6,11-dihydrodibenz[b,e]oxepins having the structural formulae:
- ##STR29## wherein R.sub.2 and R.sub.3 are the same or different and are members selected from the group consisting of hydrogen, halogen, nitro, amino, N-lower alkylamino, N,N-dilower alkylamino, lower alkanoyl, hydroxy, lower alkoxy, lower alkylthio, trifluoromethylthiol, lower alkylsulfinyl, lower alkylsulfonyl and trifluoromethyl;
- and where R.sub.2 and R.sub.3 are on adjacent carbon atoms at positions 8 and 9 or 2 and 3, R.sub.2 and R.sub.3, taken together, are methylenedioxy;
- R.sub.4 is a member selected from the group consisting of hydrogen, hydroxy, loweralkoxy, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, phenylthio, amino, formamido, and 1-imidazolyl;
- R.sub.5 is a member selected from the group consisting of hydrogen and lower alkyl;
- R.sub.4 and R.sub.5, taken together, are a member selected from the group consisting of .dbd.O and .dbd.CH-R.sub.7 wherein R.sub.7 is a member selected from the group consisting of hydrogen and phenyl;
- and
- R.sub.1 is a member selected from the group consisting of 5-tetrazolyl and carboxy;
- with the proviso that R.sub.1 is not 5-tetrazolyl, carboxy or carboxamido when R.sub.4 and R.sub.5, taken together, are .dbd.O and R.sub.2 and R.sub.3 are hydrogen;
- and the pharmaceutically acceptable salts thereof.
6 more elements
Dependencies are inferred from the claim text.