Crosslinked collagen-mucopolysaccharide composite materials
AssigneeMassachusetts Institute of Technology
InventorsIoannis V. Yannas, Philip L. Gordon, Chor Huang, Frederick H. Silver, John F. Burke
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Abstract
Composite materials are disclosed which are formed by contacting collagen with a mucopolysaccharide and subsequently covalently crosslinking the resultant polymer. These composite materials have a balance of mechanical, chemical and physiological properties which make them useful in surgical sutures and prostheses of controlled biodegradability (resorption) and controlled ability to prevent development of a foreign body reaction, and many are also useful in applications in which blood compatibility is required.
Claims11
A process for preparing a crosslinked collagen-mucopolysaccharide composite material, comprising:
- a. soaking collagen in an aqueous acidic solution having a pH of below about 6;
- b. contacting said aqueous acidic solution of collagen with a mucopolysaccharide to produce a collagen-mucopolysaccharide product;
- and,
- c. covalently crosslinking said collagen-mucopolysaccharide product to an M.sub.C value of between about 800 and about 60,000.
Dependencies are inferred from the claim text.