Reductant composition for technetium-99m and method for making technetium-99m labelled ligands

A product for reducing technetium comprising a substrate and a stannous reducing agent bound to the substrate by a chelating ligand.

A product for reducing technetium to form radiolabelled ligands comprising a stannous reducing agent bound to a substrate selected from glass and natural and synthetic polymers by a chelating ligand selected from 8-hydroxyquinoline, dihydrolipoamide, iminiodiacetic acid and ethylenediaminetriacetic acid.

A method for preparing a technetium-99m labelled ligand comprising mixing the ligand to be labelled and pertechnetate in the presence of a reductant, said reductant comprising a substrate having attached thereto a reducing complex having sufficient redox potential to reduce technetium from the +7 oxidation state to an oxidation state at which said technetium forms a relatively stable complex with said ligand to be labelled, and separating said reductant from the technetium labelled ligand.

A method for preparing a technetium-99m labelled ligand comprising mixing the ligand to be labelled and pertechnetate in the presence of a reductant, said reductant comprising stannous reducing agent bound to a substrate by a chelating ligand and separating said reductant from the technetium labelled ligand.

A method for preparing a technetium-99m labelled ligand comprising mixing the ligand to be labelled and pertechnetate in the presence of a reductant, said reductant comprising a stannous reducing agent bound to a substrate selected from glass and natural and synthetic polymers by a chelating ligand selected from 8-hydroxyquinoline, dihydrolipoamine, aminodiacetic acid and ethylenediaminetriacetic acid, and separating said reductant from the technetium labelled ligand.

A radiopharmaceutical composition comprising technetium-99m labelled ligand and a reducing agent in an amount less than 1.0 .mu.g per ml of composition.

A container having therein a ligand to be labelled with technetium-99m for use as a radiopharmaceutical composition and a reductant comprising a substrate having attached thereto a reducing complex having sufficient redox potential to reduce technetium from the +7 oxidation state to an oxidation state at which said technetium forms a relatively stable complex with said ligand to be labelled.

A container having therein a ligand to be labelled with technetium-99m for use as a radiopharmaceutical composition and a reductant comprising a stannous reducing agent bound to a substrate by a chelating ligand.

A container having therein a ligand to be labelled with technetium-99m for use as a radiopharmaceutical composition and a reductant comprising a stannous reducing agent bound to a substrate selected from glass and natural and synthetic polymers by a chelating ligand selected from 8-hydroxyquinoline, dihydrolipoamide, aminodiacetic acid and ethylenediaminetriacetic acid.

A product for reducing technetium comprising a substrate having attached thereto a reducing complex having sufficient redox potential to reduce technetium from the +7 oxidation state to an oxidation state at which said technetium forms a relatively stable complex with a ligand to be labelled, said substrate being sterile and inert under the conditions under which said product is used.