Psycho-pharmacological peptides
AssigneeAkzo N.V.
InventorsDavid de Wied, Hendrik M. Greven
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AssigneeAkzo N.V.
InventorsDavid de Wied, Hendrik M. Greven
Estimating the term…
The present invention relates to novel psycho-pharmacological active peptides and peptide derivatives of the formula: A-R-L-Ser-R.sub.1 -L-Thr-L-Pro-L-Leu-L-Val-L-Thr-B wherein R represents the amino acid residue L-Lys or L-Arg, R.sub.1 represents the amino acid residue L-Glu or L-Gln, B represents one of the following amino acid or peptide-radicals: L-Leu-OH, (.alpha.-dehydro)Leu-OH D-Leu-OH L-Leu-L-Phe-OH L-Leu-L-Phe-L-Lys-OH L-MeLeu-OH or the radical ##STR1## and A represents one of the following radicals or residues: hydrogen H-L-Glu Z.sub.1 -L-Glu Z.sub.2 -L-Ser-L-Glu- H-Q.sub.1 -L-Thr-L-Ser-L-Glu- Q.sub.2 -L-Thr-L-Ser-L-Glu- Z.sub.3 -Q.sub.1 -L-Thr-L-Ser-L-Glu- or H.sub.2 N-ALK-CO-L-Phe-Q.sub.1 -L-Thr-L-Ser-L-Glu- in which Z.sub.1 represents H-L-Ser, H-D-Ser, desamino-Ser, 2,3-dihydroxy propanoyl or H.sub.2 N-ALK-CO-, Z.sub.2 represents H-L-Thr, H-D-Thr, desamino-Thr, 2,3-dihydroxybutanoyl or H.sub.2 N-ALK-CO; Q.sub.1 represents L-Met, L-Met(O), L-Met (O.sub.2) or L-Leu Q.sub.2 represents H-D-Met, H-D-Met (O), H-D-Leu, H-D-Met (O.sub.2), desamino Met, desamino Met (O), desamino Met (O.sub.2), desamino Leu, 2-hydroxy-4-methylthiobutanoyl, 2-hydroxy-4-methylpentanoyl or the radical H.sub.2 N-ALK-CO, Z.sub.3 represents H-L-Phe, H-D-Phe, desamino Phe, 2-hydroxy-3-phenyl-propanoyl and H.sub.2 N-ALK-CO-, and ALK represents an alkylene or alkylidene group with 1-6 carbon atoms, as well as the functional derivatives thereof.
Peptide of the formula:
Dependencies are inferred from the claim text.