Process for the manufacture of cystine-containing peptides
AssigneeCiba-Geigy Corporation
InventorsBruno Kamber, Werner Rittel
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Abstract
The invention concerns an improved process for the manufacture of cystine-containing peptides from cysteine-containing aminoacid sequences whose mercapto groups are protected by trityl groups, wherein the S-trityl cysteine-containing sequences are directly oxidized with iodine to yield the cystine disulfide bond.
Claims9
Process for the manufacture of cystine-containing peptides and derivatives thereof from corresponding cysteine-containing aminoacid sequences in which the mercapto groups are protected by trityl groups, wherein the aminoacid sequence(s) containing the cysteine residues to be combined is (are) treated with iodine in a solvent in which both iodine and the peptide are at least partically soluble.
Dependencies are inferred from the claim text.