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US 4,269,846 AGranted
Heterocyclic compounds useful as anti-allergy agents
AssigneeUSV Pharmaceutical Corporation
InventorsFu C. Huang, John H. Musser
Life of this patent
Estimating the term…
Abstract
New benzoheterocyclic oxadiazolones and triazolones are described. These compounds are useful as anti-allergic reagents.
Claims21
An anti-allergic compound of the formula ##STR19## wherein:
- the dotted line indicates that the double bond may be in either position;
- R is hydrogen, alkyl, alkenyl, alkoxy, alkenyloxy, aryloxy, aralkoxy, halogen, cyano, nitro, carboxy, hydroxy, formyl, carbalkoxy, hydroxyalkyl, amino, alkylamino, trifluoromethyl, mercapto, trifluoromethoxy, alkylthio, or aminoalkyl, wherein the number of carbon atoms in the alkyl and alkenyl moieties is up to 7 and in the aryl moieties is up to 10;
- Y is N, N--R.sub.2 or CR.sub.2 wherein R.sub.2 is hydrogen, alkyl or aryl and the number of carbon atoms is up to 7 in said alkyl moiety and is up to 10 in the aryl moiety, with the proviso that when Y is NH, (R).sub.a is not hydrogen;
- a is an integer from 1 to 4;
- X and Z are independently O, S, NR.sub.2 or CR.sub.2 wherein R.sub.2 is as defined above, with the proviso that when Y is NR.sub.2, X is not CR.sub.2 ;
- and
- R.sub.1 is hydrogen, alkyl, aryl, acyl, carbalkoxy, or carbaryloxy, wherein the number of carbon atoms in is up to 7 in the alkyl and aliphatic acyl groups and is up to 10 in the aryl and aromatic acyl groups;
- and
- acid addition salts thereof.
6 more elements
2-(2-Oxo-3H-1,3,4-oxadiazol-5-yl)benzoxazole.
1-Methyl-2-(2-oxo-3H-1,3,4-oxadiazol-5-yl)-benzimidazole.
5-Chloro-2-(2-oxo-3H-1,3,4-oxadiazol-5-yl)-benzoxazole.
6-Methyl-2-(2-oxo-3H-1,3,4-oxadiazol-5-yl)-benzoxazole.
2-(2-Oxo-3H-1,3,4-oxadiazol-5-yl)benzothiazole.
2-(2-Oxo-3-acetyl-3H-1,3,4-oxadiazol-5-yl)-1-methylbenzimidazole.
2-(2-Oxo-3H-1,3,4-oxadiazole-5-yl)benzofuran.
Dependencies are inferred from the claim text.