N-Substituted N-carboxyanhydrides of .alpha.-amino acids and their application in the preparation of peptides
AssigneeProteinkemisk Institut. tilknyttet Akademiet for de tekniske Videnskaber
InventorsJohn B. Halstrom, Karoly G. Kovacs
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Abstract
N-Substituted N-carboxyanhydrides of .alpha.-amino acids, useful in peptide syntheses, and peptide synthesis process using such compounds, are disclosed. The N-substituent is penta(lower alkoxy)benzyl, or optionally substituted 9-xanthyl, 9-thioxanthyl or 9-selenoxanthyl.
Claims5
N-substituted N-carboxyanhydrides of .alpha.-amino acids, having the general formula I ##STR13## wherein R designates hydrogen or the side-chain of an .alpha.-amino acid, any functional group or functional groups in said side-chain being optionally protected, R.sub.1 and R.sub.2 together with the adjacent carbon atom designates R.sub.9 -xanthyl-, R.sub.9 -thioxanthyl- or 9-selenoxanthyl group, said group being optionally substituted in positions other than 1 and 8 with probably lower alkyl, lower alkoxy, nitro, or chloro.
Dependencies are inferred from the claim text.