Back to results
US 4,267,174 AGranted
Immune-stimulating and cancerostatic 1-acyl-2-cyanoaziridines
AssigneeBoehringer Mannheim GmbH
InventorsHerbert Berger, Rudi Gall, Wolfgang Kampe, Uwe Bicker, Rolf Kuhn
Life of this patent
Estimating the term…
Abstract
1-Acyl-2-cyanoaziridines of the formula ##STR1## wherein R is an acyl radical of a carboxylic, sulphonic, sulphinic, sulphenic, phosphonic or phosphoric acid, exhibit immune-stimulating and cancerostatic activities.
Claims24
A 1-acyl-2-cyanoaziridine of the formula ##STR17## in which R.sub.1 is (a) a cyclic aliphatic hydrocarbon radical with 3 to 7 carbon atoms,
- (b) a straight-chained or branched hydrocarbon radical with 1 to 5 carbon atoms which is mono- or di-substituted by
- (1) a carbamoyl optionally mono- or di-substituted by a lower alkyl group,
- (2) a lower alkoxy carbonyl,
- (3) a lower alkoxy or a lower alkylthio substituted by a radical or the formula ##STR18## (4) an acylamino group of the formula ##STR19## in which R.sub.5 is hydrogen, lower alkoxy, vinyl or lower alkyl, (c) a phenyl group which is substituted by a phenyl group, ##STR20## ##STR21## or a pharmacologically compatible salt thereof.
1 more element
Dependencies are inferred from the claim text.