Fluorinated aromatic polyenes
AssigneeHoffmann-La Roche Inc.
InventorsKa-Kong Chan, Beverly A. Pawson
Life of this patent
Estimating the term…
Abstract
Compounds representd by the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are lower alkyl, R.sub.4 is lower alkoxy, R.sub.6 and R.sub.8 are methyl or trifluoro methyl, R.sub.9 is formyl, hydroxymethyl, alkoxymethyl, alkanoyloxymethyl, carboxyl, alkoxycarbonyl, lower alkenoxycarbonyl, lower alkynoxycarbonyl, carbamoyl, mono(lower alkyl)-carbamoyl, di(lower alkyl)carbamoyl or N-heterocyclylcarbonyl, R.sub.5, R.sub.7, R.sub.10, R.sub.11, R.sub.12 and R.sub.13 are hydrogen or fluorine with the proviso that at least one of R.sub.5, R.sub.7, R.sub.10, R.sub.11, R.sub.12 or R.sub.13 is fluorine or at least one of R.sub.6 or R.sub.8 is trifluoro methyl, or pharmaceutically acceptable salts thereof useful as antitumor agents are disclosed.
Claims11
A compound represented by the formula ##STR39## wherein R.sub.1, R.sub.2 and R.sub.3 are lower alkyl, R.sub.4 is lower alkoxy, R.sub.8 is methyl or trifluoromethyl, R.sub.5, R.sub.10 and R.sub.11 are hydrogen of fluorine and R.sub.14 is formyl, hydroxymethyl, alkoxymethyl, dialkoxymethyl, carboxyl, alkoxycarbonyl, alkenoxycarbonyl or alkynoxy carbonyl with the proviso that when R.sub.8 is methyl one of R.sub.5, R.sub.10 and R.sub.11 is fluorine.
The compound of claim 1, 5-(4-methoxy-2,3,6-trimethylphenyl)-3-methyl-4-fluoro-2(E),4(Z)-pentadien- 1-ol.
The compound of claim 1, 5-(4-methoxy-2,3,6-trimethylphenyl)-3-methyl-4-fluoro-2(E),4(Z)-pentadiena l.
The compound of claim 1, 5-[4-methoxy-2,3,6-trimethyphenyl]-2-fluoro-3-methyl-2(Z,E),4(E)-pentadien -1-ol.
Dependencies are inferred from the claim text.