Process for preparation of prodigiosin
AssigneeKirin Beer Kabushiki Kaisha
InventorsKatsumi Nakamura, Kumpei Kitamura
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Abstract
Prodigiosin, an antibiotic, is effectively produced by culturing a novel Serratia marcescens R-2 strain. A synthetic culture medium is also provided, which contains a higher fatty acid having 12 to 18 carbon atoms, a salt thereof or an ester thereof as the sole or main source of carbon and in which a strain of Serratia marcescens having the abilities to assimilate the source of carbon and to produce prodigiosin can be cultivated to obtain prodigiosin.
Claims4
A process for preparation of prodigiosin, which comprises cultivating Serratia marcescens R-2 strain having an ATCC number of 31453 in a culture medium, thereby to produce prodigiosin in the bacterial cells or the medium, and collecting the produced prodigiosin.
A process for preparation of prodigiosin, which comprises cultivating, in a synthetic culture medium containing 0.5 to 10% by weight of a polyoxyethylene-sorbitan ester of a higher fatty acid having 12 to 18 carbon atoms as the sole or main assimilable source of carbon, a bacterial strain having the capability of assimilating the source of carbon and producing prodigiosin, said strain being a Serratia marcescens strain, thereby to produce prodigiosin in the bacterial cells or the medium;
- and separating the produced prodigiosin.
A process for preparation of prodigiosin, which comprises cultivating, in a synthetic culture medium containing 0.5 to 10% by weight of a higher fatty acid having 12 to 18 carbon atoms, a salt thereof and/or C.sub.1 to C.sub.4 alkyl ester thereof with an alcohol as the sole or main assimilable source of carbon, a bacterial strain having the capability of assimilating the source of carbon and producing prodigiosin, said strain being a Serratia marcescens strain having an ATCC number of 31453, thereby to produce prodigiosin in the bacterial cells or the medium;
- and separating the produced prodigiosin.
Dependencies are inferred from the claim text.