Prostanoid compounds and compositions
AssigneeGlaxo Group Limited
InventorsEric W. Collington, Harry Finch, Roger F. Newton, Christopher J. Wallis
Life of this patent
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Abstract
Prostanoid compounds are described having the formula: ##STR1## where A is a cyclopentane ring, which is substituted by oxo and/or hydroxy or etherified hydroxy and may be saturated or unsaturated; X is --CH.dbd.CH-- or --(CH.sub.2).sub.2 --; R is alkyl having a terminal --COOH or ester grup; and Y is amino or substituted amino, particularly heterocyclic amino. The compounds have bronchodilator activity and/or inhibit blood platelet aggregation. The preparation and pharmaceutical formulation of the compounds is also described.
Claims11
Prostanoid compounds of the general formula:
- ##STR289## wherein X is cis or trans --CH.dbd.CH-- or --(CH.sub.2).sub.2 --;
- Y is a saturated heterocyclic amino group selected from the group consisting of pyrrolidino, piperidino, piperidino substituted by hydroxy morpholino, piperazino, thiamorpholino, 1-dioxothiamorpholino, homomorpholino, hexamethyleneimino, and piperazino substituted at the second nitrogen atom by C.sub.1-7 alkyl or phenalkyl having a C.sub.1-4 alkyl portion or any of said groups substituted by one or more C.sub.1-4 alkyl groups;
- R.sup.1 is straight or branched C.sub.1-7 alkyl bearing as a terminal substituent --COOR.sup.10 where R.sup.10 is a hydrogen atom, C.sub.1-6 alkyl or C.sub.7-10 phenalkyl;
- R.sup.4 is C.sub.1-6 alkyl, C.sub.3-6 alkenyl, phenyl, benzhydryl, naphthyl-C.sub.1-3 alkyl, phen-C.sub.1-3 alkyl or phen-C.sub.1-3 alkyl wherein the phenyl group is substituted by a substituent selected from phenyl, halogen, C.sub.5-7 cycloalkyl, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, cyano, amino, benzyloxy, dialkylamino, dimethylaminomethyl, thiocarboxamido and carboxamido and the physiologically-acceptable salts thereof.
Prostanoid compounds of the general formula:
- ##STR290## wherein X is cis --(CH.dbd.CH)--;
- Y is pyrrolidino, piperidino, piperidino substituted by hydroxy, morpholino, thiamorpholino, 1-dioxothiamorpholino, piperazino, homomorpholino or hexamethyleneimino, or any of said groups substituted by one or more C.sub.1-4 alkyl groups;
- R.sup.4 is 4-phenylbenzyl or 4-cyclohexylbenzyl and the physiologically-acceptable salts thereof.
Dependencies are inferred from the claim text.