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US 4,264,607 AGranted
A40A Efrotomycin-like antibiotic in fermentation broth
AssigneeMerck & Co., Inc.
InventorsRay S. Dewey, Vincent P. Gulla, Sheldon B. Zimmerman, Satoshi Omura, Ruiko Oiwa
Life of this patent
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Abstract
There is disclosed a new antibiotic agent, A40A, produced by Streptomyces lavedulae MA-4758 (ATCC 31312) under suitable conditions. Said antibiotic shows antibacterial and growth-permittant activity.
Claims6
A composition comprising an antibacterially effective amount of A40A having the structure:
- ##STR2## wherein the pyran has the following configuration at its asymmetric centers:
- S at the hemiketal 2, S at the hydroxyl bearing carbon 4, and S at the pentadienyl side chain bearing carbon 6, or its pharmaceutically acceptable salts and a non-toxic, pharmaceutically acceptable excipient.
A composition for use as a growth-permittant in animals comprising a growth-permitting amount of A40A having the structure:
- ##STR3## wherein the pyran has the following configuration at its asymmetric centers:
- S at the hemiketal 2, S at the hydroxyl bearing carbon 4, and S at the pentadienyl side chain bearing carbon 6, or its pharmaceutically acceptable salts and an inert carrier.
A method for preparing A40A having the structure:
- ##STR4## wherein the pyran has the following configuration at its asymetric centers:
- S at the hemiketal 2, S at the hydroxyl bearing carbon 4, and S at the pentadienyl side chain bearing carbon 6, which comprises cultivating Streptomyces lavendulae ATCC 31312 in a fermentation broth containing assimilable sources of carbohydrates, nitrogen and inorganic salts under aerobic conditions until a substantial amount of A40A is produced in the fermentation broth and recovering said antibiotic.
A compound A40A having the following structure:
- ##STR5## wherein the pyran has the following configuration at its asymmetric centers:
- S at the hemiketal 2, S at the hydroxyl bearing carbon 4, and S at the pentadienyl side chain bearing carbon 6, or its pharmaceutically acceptable salts or esters.
Dependencies are inferred from the claim text.