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US 4,261,975 AGranted
Viral liposome particle
AssigneeMerck & Co., Inc.
InventorsW. Wardle Fullerton, Bohdan Wolanski
Life of this patent
Estimating the term…
Abstract
The outer membrane of influenza virus is attached to a liposome by two different techniques. In addition, one of the techniques allows the entrapment of intact virus, usually one virus per liposome. The techniques can be performed with either influenza virus A or B.
Claims10
A spikoliposome particle comprising a liposome having attached to its outer surface the intact outer membrane layer of influenza virus having attached spikes, the outer membrane attached by having been reacted with both
- a positively charged quaternary ammonium salt of an amino-containing surfactant of the formulas ##STR2## wherein R.sup.1 is a straight or branched chain alkyl radical of from 12 to 20 carbon atoms, R.sup.2 and R.sup.3 may be the same or different and are alkyl of from 1 to 3 carbon atoms, and R.sup.4 is benzyl, R.sup.5 and R.sup.6 together are a 5-membered or 6-membered heterocyclic radical, and X is a halide ion,
- and a phospholipid.
Dependencies are inferred from the claim text.