Allergen-containing substances
AssigneePharmacia Corporation
InventorsWeng Y. Lee, Alec Sehon
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Abstract
This invention pertains to allergen-containing substances, methods of preparing the same and using the same as immunologically specific suppressants of the production of reaginic antibodies directed to the allergen in question. The allergen-containing substances can be characterized as covalent conjugates of the allergen molecules with non-immunogenic water-soluble polymers. The degree of conjugation is such that the conjugates are rendered tolerogenic as well as substantially non-allergenic and non-immunogenic. The new conjugates are useful for immunologically specific suppression of common allergies in mammals, including humans, which are mediated by reaginic antibodies of the IgE class.
Claims3
The method for immunologically specific suppressing of the production of reaginic antibodies directed to the allergen in question which comprises injecting into mammals suffering from an allergy a therapeutically efficient dose, and in a pharmaceutically acceptable manner, at least one allergen-containing substance being characterized as covalent conjugates of immungenic allergen molecules with non-immunogenic water-soluble polymers, the degree of conjugation being such that the conjugates are rendered tolerogenic.
Dependencies are inferred from the claim text.