Disulfide derivatives having S--S exchange reactivity

Abstract

A disulfide derivative, having S--S exchange reactivity, of the formula R.sub.1 --S--S--R.sub.2 --CO--R.sub.3).sub.n R.sub.4 [I] wherein R.sub.1 is 2-benzothiazolyl or 2-pyridyl-N-oxide, R.sub.2 is alkylene having optionally free or protected functional groups, R.sub.3 is the carboxyl residue of an amino acid or lower polypeptide, R.sub.4 is carboxyl or a reactive derivative thereof or protected carboxyl or imidate, and n is 0 or 1.

Dependencies are inferred from the claim text.