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AssigneeUniversity of Kentucky Research Foundation
InventorsJohn W. Triplett, Randall B. Smith
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A process for preparing bromine-containing dyes labelled with gamma-emitting isotopes of bromine, and the product thereof which is useful as an imaging agent for the hepato-biliary system, particularly in dynamic imaging methods. The dyes prepared are from the class of triarylmethane dyes, and also from the phthalein subclass of the class of xanthene dyes, and the labelling thereof is effected with .sup.76 Br, .sup.77 Br or .sup.82 Br. The process for preparing these dyes involves reacting the non-brominated dye precursor with either .sup.76 Br.sub.2, .sup.77 Br.sub.2 or .sup.82 Br.sub.2. This is a substitution type of reaction in which a ring hydrogen is substituted by either .sup.76 Br, .sup.77 Br or .sup.82 Br.
A process for imaging the liver or biliary tract of a patient comprising the steps of:
A process for serially imaging the liver and biliary tract of a patient comprising the steps of:
A process as recited in claim 4 in which the gamma-emitting isotope of bromine is selected from the group consisting of .sup.76 Br, .sup.77 Br and .sup.82 Br.
A process for imaging the liver or biliary tract of a patient comprising the steps of:
Dependencies are inferred from the claim text.