Chemical compounds
AssigneeNyegaard & Co. A/S
InventorsVegard Nordal, Hugo Holtermann
Life of this patent
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Abstract
Compounds of the formula: ##STR1## wherein R represents the group --CH.sub.2 CH.sub.2 OH or --CH.sub.2 CHOHCH.sub.2 OH, particularly in racemic or optically active form, are employed as active ingredients in X-ray contrast agents for intracerebral, but particularly for vascular use. The compounds are prepared by reacting 5-(N-acetamido)-2,4,6-triiodo-N,N'-bis-(2,3-dihydroxypropyl)isophthalamide or an O-acetyl derivative thereof with an appropriate hydroxyalkylating agent and subsequently, if necessary, hydrolysing any unwanted O-acetyl groups.
Claims4
Compounds of the general formula:
- ##STR9## (wherein R represents the group --CH.sub.2 CH.sub.2 OH or --CH.sub.2 CHOHCH.sub.2 OH).
5-(N-2-Hydroxye thylacetamido)-2,4,6-triiodo-N,N'-bis-(2,3-dihydroxypropyl)isophthalamide.
5-(N-2,3-Dihydroxypropyl)-2,4,6-triiodo-N,N'-bis-(2,3-dihydroxypropyl)is ophthalamide.
The compound:
- (+)-5-(N-2-Hydroxyethylacetamido)-2-4,6-triiodo-N,N'-bis(2,3-dihydroxypropy l)isophthalamide;
- (-)-5-(N-2-Hydroxyethylacetamido)-2,4,6-triiodo-N,N'-bis(2,3-dihydroxypropy l)isophthalamide;
- or
- racemic 5-(N-2-Hydroxyethylacetamido)-2,4,6-triiodo-N,N'-bis(2,3-dihydroxypropyl)i sophthalamide.
Dependencies are inferred from the claim text.