Microbiological reduction of 15-ketoprostaglandin intermediates
AssigneeSchering Corporation
InventorsKlaus Kieslich, Bernd Raduchel, Werner Skubalia, Helmut Vorbruggen, Helmut Dahl
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Abstract
A process for the preparation of a 15 .alpha.-hydroxyprostaglandin intermediate of the formula ##STR1## wherein R.sub.1 is phenoxymethyl, phenoxymethyl substituted on the phenyl moiety by halogen or trifluoromethyl, or alkyl of 1-5 carbon atoms, and R.sub.2 is hydrogen, acetyl, benzoyl or p-phenylbenzoyl, which comprises stereospecifically microbiologically reducing a corresponding 15-ketone of the formula ##STR2## with a strain of the microorganism Kloeckera, Saccharomyces or Hansenula.
Claims7
A process for the preparation of a 15.alpha.-hydroxyprostaglandin intermediate of the formula ##STR6## wherein R.sub.1 is phenoxymethyl, phenoxymethyl substituted on the phenyl moiety by halogen or trifluoromethyl, or alkyl of 1-5 carbon atoms, and
- R.sub.2 is hydrogen, acetyl, benzoyl or p-phenylbenzoyl,
- comprising stereospecifically, microbiologically reducing a corresponding 15-ketone of the formula ##STR7## with a strain of the microorganism Kloeckera, Saccharomyces or Hansenula.
Dependencies are inferred from the claim text.