Treatment of arthritis and substances for use in such treatment
AssigneeProter S.p.A.
InventorCharles A. Friedmann
Life of this patent
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Abstract
1,8-Dihydroxy and 1,8-diacetoxy anthraquinones and derivatives thereof are used to treat the symptoms of arthritis.
Claims13
A method of treating the symptoms of arthritis comprising administering an effective amount of an anthraquinone derivative derived from one of the following formulae A and B ##STR3## in which formulae X is an --OH or a --NH.sub.2 group, in either of which there is a further substituent of at least one solubilising group selected from --(CH.sub.2).sub.n --COOH groups, --CHOH--(CH.sub.2).sub.n --COOH groups, --CO--(CH.sub.2).sub.n --COOH groups, --CH.sub.2 --O--(CH.sub.2).sub.n --COOH groups, --CH.sub.2 --O--CO --(CH.sub.2).sub.n --COOH groups, --O--(CH.sub.2).sub.n --COOH groups, --CH.sub.2 NH.sub.2 groups, --CH.sub.2 NHMe groups, --CH.sub.2 --NMe.sub.2 groups, --CH.sub.2 --NHEt groups, --CH.sub.2 --NEt.sub.2 groups, --SO.sub.3 H groups, --SO.sub.2 NH.sub.2 groups and pharmaceutically acceptable salts of such groups, wherein n is 0, or any integer not exceeding 10, and which may be substituted with no more than one additional hydroxyl group, or a pharmacological equivalent of a hydroxyl group, that must be in the 4,5 or 8 positions only, and in which there may be one or more inactive substituents selected from methyl, ethyl, propyl, butyl, methoxy and ethoxy groups, chlorine, bromine and iodine atoms, or the pharmacological equivalent of any such anthraquinone derivative.
A method of treating the symptoms of arthritis comprising administering to an animal suffering therefrom an effective amount of 1,8-diacetoxy-3-carboxyanthraquinone or a pharmaceutically acceptable ester thereof.
A pharmaceutical composition for the treatment of the symptoms of arthritis in a dosage form containing as the agent for treating the symptoms of arthritis from about 10 mg to about 300 mg of 1,8-diacetoxy-3-carboxyanthraquinone or a pharmaceutically acceptable ester thereof, together with a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.