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US 4,242,507 AGranted
Sulfonic acid esters
AssigneeFujisawa Pharmaceutical Co., Ltd.
InventorsMasumi Itoh, Jiyoji Notani
Life of this patent
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Abstract
A novel process for the amidation or esterification which comprises reacting a compound having a carboxy group with a compound having an amino or imino group which can be acylated or with a compound having a hydroxy group in the presence of a sulfonic acid ester of the formula: R.sub.1 --SO.sub.2 --OR.sub.2 wherein R.sub.1 is an organic group and R.sub.2 O-- is a residue of a strongly acidic N-hydroxy compound as a condensation agent, and a novel sulfonic acid ester useful as such a condensation agent and a process for the preparation thereof.
Claims57
A sulfonic acid ester of the formula:
- R.sub.1 '--SO.sub.2 --OR.sub.2 '
- wherein R.sub.1 ' is a member selected from the group consisting of alkyl having 1 to 6 carbon atoms, oxo substituted bicycloalkylalkyl having 7 to 10 carbon atoms in the bicycloalkyl moiety and having 1 to 6 carbon atoms in the alkyl moiety, phenylalkyl having 1 to 6 carbon atoms in the alkyl moiety, phenylalkenyl having 2 to 6 carbon atoms in the alkenyl moiety, phenyl,
- 2,4,6-trimethylphenyl, alkylphenyl having one alkyl having 1 to 6 carbon atoms in the alkyl group thereof, phenyl having 1 to 3 substituent(s) selected from the group consisting of alkenyl having 2 to 6 carbon atoms, halogen, and nitro, and .beta.-pyridyl, and R.sub.2 'O-- is a member selected from the group consisting of benzotriazolyloxy, benzotriazolyloxy having one substituent selected from the group consisting of nitro, halogen and alkenyl having 2 to 6 carbon atoms, and oxo substituted dihydrobenzotriazinyloxy, with the proviso that when R.sub.1 ' is phenyl having one alkyl, R.sub.2 'O-- is not benzotriazolyloxy.
Dependencies are inferred from the claim text.