Cultivating streptomyces to produce an esterase inhibitor
AssigneeZaidan Hojin Biseibutsu Kagaku Kenkyu Kai
InventorsHamao Umezawa, Takaaki Aoyagi, Tomio Takeuchi, Masa Hamada, Masaaki Ishizuka
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Abstract
A new physiologically active substance named esterastin is now provided, which inhibits the activity of esterase and is useful as an immunosuppressive drug. Esterastin is produced by cultivating a micro-organism Streptomyces MD4-C1 identified as FERM-P 3723 or ATCC. 31336 in a culture medium under aerobic conditions and recovering it from the resulting culture. Esterastin is the compound having the formula ##STR1##
Claims4
The process for the production of the compound having the formula ##STR4## denominated esterastin, which comprises cultivating an esterastin-producing strain of Streptomyces lavendulae having the identifying characteristics of A.T.C.C. 31336 under submerged aerobic conditions in a nutrient medium containing assimilable carbon and nitrogen sources for a period of time sufficient to produce a substantial amount of esterastin in the culture medium and recovering esterastin from said medium.
Dependencies are inferred from the claim text.