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AssigneeVeb Arzneimittelwerk Dresden
InventorsWerner Grawert, Ludwig Schiedt, Brigitte Neumann, Karlheinz Heidenbluth, Christoph Dauth, Rudolf Schirutschke, Monika Muller
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A process for isolating ergot alkaloids from culture suspensions, in which after mechanical filtration, the residue is dried in a fluidized drying bed and the alkaloids are extracted with an aprotic organic solvent, reextracted with a weakly acidic aqueous solution which is subsequently made basic, and finally extracted with a water-immiscible organic solvent, from which the alkaloids are isolated in a conventional manner. In certain instances, the culture suspension is stirred with an adsorbent clay to entrain the water-soluble alkaloids.
A process for isolating ergot alkaloids from a raw culture suspension, comprising stirring said suspension with an absorbent clay selected from the group consisting of fuller's earth, bentonite and a bleaching earth;
A process for isolating ergot alkaloids from a raw culture suspension, in which said alkaloids are contained predominantly within culture cell mass, comprising mechanically filtering said suspension, thereby isolating a filtration residue;
Dependencies are inferred from the claim text.