Bis(nitrosoureido)-polyol derivatives
AssigneeRichter Gedeon Vegyeszeti Gyar Rt.
InventorsTibor Horvath, Endre Csanyi, Sandor Eckhardt, Emilia Kiraly nee Vida
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Abstract
The invention relates to bis(nitrosoureido)-polyol derivatives of general formula I B.sub.1 --A--B.sub.2 (I) wherein A stands for an open chain polyol comprising 4 to 6 carbon atoms or a six-membered cyclic polyol, and B.sub.1 and B.sub.2 being attached to two different carbon atoms of the chain A, are identical or different, and stand for a group of general formula II ##STR1## wherein X stands for a halogen atom and Y and Z stand for a hydrogen atom or a nitroso group, with the restriction, that in B.sub.1 and B.sub.2 Y and Z must be different. The above compounds possess valuable cytostatic activity.
Claims18
1,4-Bis[3-(2-chloroethyl)-N-nitrosoureido]-1,4-dideoxy-D,L-threitol.
1-[3-(2-Chloroethyl)-3-nitrosoureido]-4-[3-(2-chloroethyl)-1-nitroso ureido]-1,4-dideoxy-D,L-threitol.
1,4-Bis[3-(2-chloroethyl)-1-nitrosoureido]-1,4-dideoxy-D,L-threitol.
1,4-Bis[3-(2-chloroethyl)-3-nitrosoureido]-1,4-dideoxy-D,L-threitol.
1,4-Bis[3-(2-chloroethyl)-N-nitrosoureido]-1,4-dideoxy-erythritol.
1-[3-(2-Chloroethyl)-3-nitrosoureido]-4-[3-(2-chloroethyl)-1-nitro soureido]-1,4-dideoxy-erythritol.
1,4-Bis[3-(2-chloroethyl)-1-nitrosoureido]-1,4-dideoxy-erythritol.
1,4-Bis[3-(2-chloroethyl)-3-nitrosoureido]-1,4-dideoxy-erythritol.
1,6-Bis[3-(2-chloroethyl)-N-nitrosoureido]-1,6-dideoxy-D-mannitol.
1-[3-(2-Chloroethyl)-3-nitrosoureido]-6-[3-(2-chloroethyl)-1-nitr osoureido]-1,6-dideoxy-D-mannitol.
1,6-Bis[3-(2-chloroethyl)-1-nitrosoureido]-1,6-dideoxy-D-mannitol.
1,6-Bis[3-(2-chloroethyl)-3-nitrosoureido]-1,6-dideoxy-D-mannitol.
1,3-Bis[3-(2-chloroethyl)-3-nitrosoureido]-1,2,3-trideoxy-scylloin ositol.
1,3-Bis[3-(2-chloroethyl)-3-nitrosoureido]-1,3-dideoxy-scylloinositol.
1,6-Bis[3-(2-chloroethyl)-N-nitrosoureido]-1,6-dideoxy-galactitol.
1-[3-(2-Chloroethyl)-3-nitrosoureido]-6-[3-(2-chloroethyl)-1-nitro soureido]-1,6-dideoxy-galactitol.
1,6-Bis[3-(2-chloroethyl)-1-nitrosoureido]-1,6-dideoxy-galactitol.
1,6-Bis[3-(2-chloroethyl)-3-nitrosoureido]-1,6-dideoxy-galactitol.
Dependencies are inferred from the claim text.